GLP-1 Resource Center

What supplements should I take on Ozempic or Wegovy?

GLP-1 medications substantially reduce food intake. When you eat significantly less, your body receives significantly less of the vitamins, minerals, electrolytes, and protein it depends on. The right supplements do not mimic GLP-1. They are formulated around what tends to fall when you eat substantially less.*

The core problem

A 2025 joint advisory from four professional societies, published by Mozaffarian and colleagues in Obesity, reported that calorie intake can fall by 16 to 39% across the GLP-1 drug class. Micronutrient intake falls with it. Protein intake falls with it. Electrolyte intake falls with it. Your medication was not designed to compensate for these losses.

What the evidence supports

A comprehensive multivitamin. When food intake drops significantly, so does intake of B vitamins, vitamin D, zinc, iron, magnesium, and folate. A standard multivitamin is not calibrated for a 16 to 39% caloric deficit. A formula built for eating substantially less is the more sensible choice.*

Electrolytes with B vitamins. Food accounts for roughly 20% of daily fluid intake. Eating significantly less means your total fluid and electrolyte intake drops even if your water consumption stays the same. Lower sodium, potassium, and magnesium intake can contribute to the brain fog, muscle cramps, and fatigue many GLP-1 patients attribute to the medication itself.

A high-quality probiotic. GLP-1 medications slow gastric emptying by design, and eating less usually means eating less fiber, which is what feeds the beneficial bacteria your digestive system depends on. A probiotic is formulated to support the microbiome through that change.*

Protein. Across GLP-1 trials the share of weight lost as lean mass depends on the medication: about 26 percent on tirzepatide, and up to 45 percent on semaglutide, with a class-wide average near 30 percent and reported figures ranging from 20 to 50 percent.* In the SURMOUNT-1 DXA substudy the placebo group lost the same ratio as the treatment group, 25 percent against 26 percent, so this is weight loss behaving as weight loss rather than the medication doing something unusual. Bear in mind that fat-free mass measured by DXA includes water, glycogen, and connective tissue, so it is not skeletal muscle alone. Most guidelines recommend 1.0 to 1.2 g of protein per kg of body weight per day during active weight loss, and a 2026 review recommends 1.2 to 1.5 g/kg/day.

Creatine monohydrate. Creatine monohydrate at 5,000mg daily has been studied extensively. A June 2026 meta-analysis in JISSN, covering seven randomised trials across 608 postmenopausal women, found lean mass higher by 0.37kg and leg press strength higher by 7.5kg, but only at 5g or more daily combined with resistance movement, and no effect at 3g or less or without it. Evidence during GLP-1 treatment specifically is still emerging, and we do not claim more than the research shows. See The Research Behind TAKE for the honest picture.

What supplements are not necessary on GLP-1

You do not need supplements that claim to boost GLP-1 naturally or mimic its effects. The category to focus on is nutritional support for reduced intake, not appetite or metabolic intervention.

The TAKE approach

TAKE was formulated specifically for people on GLP-1 medications. Each of The Eight Essentials is formulated around a specific nutritional or physiological consequence that commonly surfaces during treatment.* View The Eight Essentials. For a starting point, The Foundation System covers the three most universal needs: nutrition, gut health, and electrolytes.*

These statements have not been evaluated by the Food and Drug Administration. TAKE products are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Always speak with your healthcare provider about medication side effects or medical concerns.