GLP-1 Resource Center

What supplements should I take on Ozempic or Wegovy?

GLP-1 medications dramatically reduce food intake. When you eat significantly less, your body receives significantly less of the vitamins, minerals, electrolytes, and protein it depends on. The right supplements do not mimic GLP-1. They address what GLP-1 treatment takes away.

The core problem

Clinical research published in Obesity Reviews in 2026 confirmed that calorie intake can drop by 16 to 39% during GLP-1 treatment. Micronutrient intake drops with it. Protein intake drops with it. Electrolyte intake drops with it. Your medication was not designed to compensate for these losses.

What the evidence supports

A comprehensive multivitamin. When food intake drops significantly, so does intake of B vitamins, vitamin D, zinc, iron, magnesium, and folate. A standard multivitamin is not calibrated for a 30 to 50% caloric deficit. You need one formulated for the gaps GLP-1 treatment creates.

Electrolytes with B vitamins. Food accounts for roughly 20% of daily fluid intake. Eating significantly less means your total hydration and electrolyte intake drops even if your water consumption stays the same. Sodium, potassium, and magnesium depletion causes the brain fog, muscle cramps, and fatigue many GLP-1 patients attribute to the medication itself.

A high-quality probiotic. GLP-1 medications slow gastric emptying by design. Slower transit disrupts the gut microbiome and depletes the beneficial bacteria your digestive system depends on.

Protein supplementation. Research consistently shows that up to 40% of weight lost on GLP-1 medications is lean muscle mass. Adequate protein intake is the most evidence-backed way to protect muscle during rapid weight loss.

Creatine monohydrate. 5,000mg of creatine monohydrate daily is one of the most thoroughly researched interventions for preserving lean muscle during caloric restriction.

What supplements are not necessary on GLP-1

You do not need supplements that claim to boost GLP-1 naturally or mimic its effects. The supplement category to focus on is nutritional support for depletion, not appetite or metabolic intervention.

The TAKE approach

TAKE was formulated specifically for people on GLP-1 medications. Each of The Eight Essentials addresses a specific nutritional or physiological consequence of treatment. View The Eight Essentials. For a complete starting point, The Foundation System covers the three most universal gaps: nutrition, gut health, and electrolytes.

These statements have not been evaluated by the Food and Drug Administration. TAKE products are not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement.