GLP-1 Resource Center

How do I deal with loose skin on Ozempic?

Loose skin after significant weight loss on GLP-1 medications is one of the most common and least anticipated consequences of treatment. It is not caused by the medication directly. It follows from the speed and scale of fat loss, and from factors such as age and genetics that are not within anyone's control.

Why rapid weight loss leaves loose skin

Skin is elastic but has limits. When fat is lost rapidly, as it often is on GLP-1 medications, the skin does not contract at the same rate. The result is skin that was stretched by fat that no longer fills it. The degree of looseness depends on age, speed of weight loss, total amount lost, how long the weight was carried, genetics, sun exposure history and smoking history. Most of these are not modifiable after the fact.

What actually helps, and what does not

This is the part the supplement industry tends to blur. No oral supplement has been shown to change skin elasticity or to tighten loose skin after weight loss, and TAKE makes no such claim about any of its products. Collagen powders, marine peptides and vitamin blends are widely marketed for this purpose and the evidence for meaningful skin retraction after major weight loss is not there.

Where loose skin is significant enough to affect comfort, hygiene or daily life, the people to speak to are a dermatologist and a plastic surgeon. Body contouring surgery is the only intervention with a reliable effect on excess skin, and some procedures are covered by insurance when skin folds cause recurrent irritation or infection. A dermatologist can also advise on non-surgical options and set realistic expectations about what they do and do not achieve.

Where nutrition does matter

Collagen is a structural protein, and collagen synthesis requires adequate dietary protein and vitamin C.* When intake falls sharply, as it commonly does on a suppressed GLP-1 appetite, protein and micronutrient intake can fall below what the body uses day to day. Meeting protein and vitamin C intake is worth doing for general nutritional reasons.* It is not a treatment for loose skin, and it will not prevent it.

Most guidelines suggest 1.0 to 1.2 g/kg of body weight per day during active weight loss, and a 2026 review recommends 1.2 to 1.5 g/kg. If your intake has fallen sharply, ask your clinician about bloodwork rather than working from symptoms.

The TAKE approach

TAKE Nourish is a plant protein formulated to help meet daily protein intake during treatment: 21g per 34.7g serving in Chocolate, 20g per 35g serving in Vanilla.* It is vegan, with no dairy, whey or gluten. Fava bean protein measures a DIAAS of 0.67 in cooked whole beans, limited by histidine, so neither protein source stands alone as a high quality protein, which is why the two are blended. TAKE Complete supplies 150mg of vitamin C alongside its other vitamins and minerals.* Note that TAKE Complete contains saw palmetto and is not suitable in pregnancy, when nursing, or when trying to conceive.

Neither product is offered as a remedy for loose skin, because no supplement is.

These statements have not been evaluated by the Food and Drug Administration. TAKE products are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Always speak with your healthcare provider about medication side effects or medical concerns.