Clinical Evidence

What We Do Not Claim

Most supplement brands tell you only what their ingredients do. This page is the other half. Every statement below is something we could say about our own products and have chosen not to, because the evidence does not support it. We publish it because a brand that only tells you the good half has not told you anything you can rely on.

We do not claim creatine holds onto muscle on its own

A meta-analysis published in the Journal of the International Society of Sports Nutrition in June 2026 pooled seven randomised, placebo-controlled trials across 608 postmenopausal women and found creatine improved lean mass by 0.37kg and leg press strength by 7.5kg against placebo. The condition attached to that result is the part most brands leave out: the benefit appeared at 5 grams or more daily combined with resistance movement. Trials at 3 grams or less, and trials without resistance movement, found no measurable effect at all. Bone mineral density was unchanged, so we make no bone claim.

No trial has studied creatine in people using GLP-1 medications. A May 2026 review in Metabolites placed creatine among adjunctive options supported mainly by indirect evidence, with protein intake and resistance movement as the foundation, and the study closest to this population, in women after bariatric surgery, was negative. Creatine is safe and well tolerated at 3 to 5g daily across long-term use, with adverse events comparable to placebo and renal indices unchanged. Until a trial in GLP-1 users reports, that is the whole of what we will say, and it is why TAKE Build is sold as support for the work rather than as a substitute for it.

We do not claim either of our protein sources stands alone as a high-quality protein

Fava bean protein measures a DIAAS of 0.67 in cooked whole beans, limited by histidine, which sits below the threshold for a high-quality standalone protein.

On the fermented yeast protein, we have not been able to locate peer-reviewed human data on the branded ingredient itself, and the wider yeast protein literature is preclinical. That is precisely why TAKE Nourish blends the two rather than relying on either alone, and why we describe it as a blend rather than as a superior protein.

We do not claim topical peptides regrow hair

Molecules above roughly 500 daltons do not meaningfully cross intact skin. The growth factors used in cosmetic hair serums range from about 6,000 to 45,000 daltons. The only independent clinical trial of a topical growth-factor hair serum reported that no participant achieved meaningful hair preservation.

The studies that do show benefit from growth factors use injection or microneedling, which bypasses the skin barrier entirely. They are not evidence for a serum you apply to your scalp. The evidence in TAKE Regrowth rests on rosemary and saw palmetto, and Regrowth is a cosmetic scalp serum rather than a hair loss treatment.

We do not claim TAKE Hydrate replaces a significant electrolyte loss

Hydrate provides sodium 100mg, potassium 200mg, calcium 40mg and magnesium 20mg per 5.4g scoop. That is a small fraction of a day's electrolyte intake, and it is formulated to make daily fluid easier when plain water is unappealing, not to correct a deficit or to replace what is lost through heavy sweating or illness. TAKE Build carries ten times Hydrate's sodium, and the two are not interchangeable. If you have been told you are low in an electrolyte, that is a conversation with your prescriber, not a scoop of powder.

We do not claim a higher culture count is better

A review of probiotic dose-response found a clear relationship between dose and outcome only for antibiotic-associated diarrhea, and none for bowel function or general digestive outcomes. TAKE Flora's count sits within the range used in clinical studies. Larger numbers on a label are not evidence of anything, and we will not present ours as though they were.

Flora contains fructooligosaccharide at 24mg, which is present to feed the cultures it ships with rather than as a dietary prebiotic dose. Prebiotic research uses grams. We do not sell Flora as a prebiotic supplement.

We do not claim GLP-1 medications damage your gut microbiome

A systematic review of 38 studies found only nine conducted in humans, most reporting no change in microbial diversity, and concluded that assertions of clinically significant microbiome modulation by these medications should be treated circumspectly.

The narrower and better supported point is the one we make instead. Eating substantially less usually means eating less fiber, and fiber is what feeds the organisms your digestive system depends on.*

We do not claim fiber increases gut diversity

Across 64 randomized trials, fiber supplementation increased Bifidobacterium and Lactobacillus and raised faecal butyrate. The same analysis found no effect on microbial diversity. Claims that fiber makes your gut more diverse are not supported by that evidence.

We do not claim biotin will improve your hair

Every reported case of improvement with biotin involved an underlying pathology, such as biotin deficiency or an inherited hair disorder. The authors of that review concluded there is insufficient evidence for supplementation in people with normal biotin status. Biotin is included in TAKE Complete as a nutrient during a period of reduced food intake, not as a hair claim. Worth knowing separately: biotin at the level in TAKE Complete can interfere with some laboratory blood tests, including thyroid and cardiac markers, so tell whoever is taking your blood that you are taking it.

We do not claim to know every amount in our own products

Three TAKE products contain proprietary blends, where the manufacturer discloses the blend total and the ingredient order but not the individual amounts: the three blends in TAKE Complete, the 905mg sleep blend in TAKE Rest, and the 800mg probiotic blend in TAKE Flora. Where we do not have a number, we say so rather than implying one. Ingredient order is descending by weight, which is why we tell you that ashwagandha sits twelfth of fourteen in Rest rather than putting it on the front of the page.

We do not claim TAKE has been clinically tested

No trial has studied our products. What has been studied are the individual nutrients and ingredients, in the populations and at the doses set out on our research page. We formulate from that evidence. We do not pretend that is the same thing as testing the finished product, and neither should any brand that has not done it.

How to check any of this

Every statement above has its citation on The Research Behind TAKE, with sample sizes, populations and study designs, and a note wherever those change how a finding should be read. For the ingredient reasoning behind each product, see The Science Behind TAKE.

Where a claim on this site is not supported by evidence we can point to, we would rather remove the claim than find a study that almost fits. If you find something here that does not hold up, tell us at care@takecomplete.com and we will correct it.

*These statements have not been evaluated by the Food and Drug Administration. TAKE products are not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement, particularly while taking prescription medication.