The science behind TAKE.
Every ingredient chosen for a specific reason. Here is what is inside each Essential and the research behind why it was selected for people on GLP-1 medications.
Protein. The nutrient GLP-1 medications make it hardest to get enough of.
Muscle is metabolically active tissue. It burns calories at rest, supports blood glucose, and underpins physical function. When lean mass decreases, resting metabolic rate may drop, weight loss may slow, and body composition can shift even as the number on the scale goes down.
With appetite suppressed by medication, reaching the clinical protein target from food alone is extremely difficult. A single scoop of TAKE Nourish supports that goal with 20g of complete protein in under 200 calories, with zero digestive disruption.
A complete amino acid profile with exceptional digestibility, particularly important when GLP-1 medications slow gastric emptying and may affect protein absorption. Delivers clean protein without the bloating or discomfort of whey or standard plant proteins.
Fermentation pre-digests proteins into more bioavailable peptide forms. Absorbs faster and more completely than conventional sources, a meaningful advantage when digestive capacity may be reduced on GLP-1 medications.
Probiotic delivery. Why most probiotics fail before they start.
Most probiotics are destroyed by stomach acid before they reach the intestine. Studies show conventional probiotic products can lose up to 90% of their viable cultures before reaching the colon. This makes most of the probiotic market functionally ineffective.
Conventional probiotics can lose up to 90% of viable cultures before reaching the colon.
International Journal of Pharmaceutics, PubMedA patented marine polysaccharide delivery system that encapsulates each probiotic strain in a double-layered protection matrix, surviving the acidic environment of the stomach and delivering live bacteria directly to the gut where they are needed.
View Research →Lactobacillus Acidophilus, Bifidobacterium Lactis, Lactobacillus Plantarum, Lactobacillus Paracasei, and Prebiotic FOS. Each strain chosen for a specific function in supporting gut microbiome health during GLP-1 treatment.
View Research →Sleep. Why GLP-1 treatment commonly affects it and how Rest was formulated in response.
When food intake drops substantially, tryptophan availability may fall, which can reduce serotonin synthesis. Lower serotonin is associated with disrupted mood, elevated anxiety, and compromised sleep onset. This is a physiological response to eating significantly less, not a psychological one.
Rapid weight loss may simultaneously affect cortisol rhythms. Elevated cortisol at night is associated with the sleep disruption commonly reported by GLP-1 patients.
Caloric restriction may suppress melatonin precursors and affect cortisol rhythm, two mechanisms associated with impaired sleep quality.
TAKE Rest formulation rationaleA direct precursor to serotonin that bypasses the dietary tryptophan pathway. Does not depend on food intake to support serotonin synthesis.
View Research →Multiple randomised controlled trials have demonstrated KSM-66 ashwagandha's ability to support reduced serum cortisol levels with consistent daily use. Addresses the elevated nighttime cortisol associated with GLP-1-related sleep disruption.
View Research →Each capsule delivers 5mg of melatonin. The recommended serving is 2 capsules for a full 10mg dose, consistent with the research literature's effective range for sleep onset support. Supports circadian rhythm regulation commonly disrupted during GLP-1 treatment.
View Research →Chosen specifically over Magnesium Oxide for its superior bioavailability and its role in supporting the parasympathetic nervous system, the physiological state associated with deep, restorative sleep.
View Research →
Creatine. The most researched performance ingredient for lean muscle support.
Over 500 peer-reviewed studies support creatine monohydrate's efficacy and safety, making it one of the most extensively validated performance ingredients in existence. For people on GLP-1 medications, it addresses one of the most consequential risks of rapid weight loss: lean mass loss alongside fat loss.
A full clinical dose per serving. Supports muscle strength, cellular hydration, and recovery. Used alongside TAKE Nourish, it supports comprehensive lean mass maintenance throughout GLP-1 treatment.
View Research →Sodium (as Sea Salt) 1,000mg, Magnesium (as Magnesium Malate) 60mg, Potassium (as Potassium Chloride) 200mg. Magnesium Malate chosen specifically for its superior absorption and role in ATP energy production.
Electrolytes and B-vitamins. Why drinking more water is not enough.
GLP-1 medications reduce food intake. Food accounts for roughly 20% of daily fluid intake, so eating significantly less means total hydration may decrease even when water consumption stays the same. More critically, electrolyte changes may contribute to brain fog, muscle cramps, and fatigue that plain water cannot support.
B12 is among the most commonly depleted nutrients during GLP-1 treatment. TAKE Hydrate delivers the full B-vitamin spectrum including B1, B2, B3, B5, B6, B12, and Folate at meaningful doses with every serving.
Sodium 100mg, Potassium 200mg, Magnesium 20mg, Calcium 40mg. Clean electrolyte profile with no sugar and no artificial sweeteners.
Peptide science. How bioengineered signal proteins support hair follicle activity.
Rapid weight loss may trigger telogen effluvium, a stress-induced shedding phase where follicles enter dormancy prematurely. Combined with protein and micronutrient gaps from significantly reduced food intake, GLP-1-related hair changes can be significant. TAKE Regrowth supports the three primary areas at the follicle level.
Epidermal Growth Factor. Supports cell regeneration and follicle activity by signalling dermal papilla cells directly.
Supports blood flow to the scalp and follicle health during the dormancy phase associated with rapid weight loss.
Supports the active growth phase of the hair cycle, helping counter the premature dormancy associated with rapid weight loss.
Rosemary oil was found to be as effective as 2% minoxidil for increasing hair count after six months, without the scalp itching and side effects.
SKINmed Journal, 2015Associated with DHT support and improved scalp microcirculation. Multiple peer-reviewed studies have compared rosemary extract favorably to topical minoxidil 2% for scalp and hair health.
View Research →Associated with inhibition of 5-alpha reductase, the enzyme involved in DHT production, the primary hormonal driver of pattern hair loss. Present in both Regrowth topically and Complete systemically.
View Research →Digestive regularity. Supporting comfort during slowed gastric transit.
GLP-1 medications slow gastric emptying by 20 to 40%. This is how they reduce appetite. But slowed transit may affect motility, microbiome diversity, and contribute to the constipation and bloating many GLP-1 patients experience but few discuss with their prescribing physician.
A clinically relevant dose of soluble fiber that supports stool consistency, slows glucose absorption, and promotes healthy bowel transit to support digestive comfort during GLP-1 treatment.
View Research →Amylase, Lactase, Lipase, and Cellulase from fermented cereals. Supports breakdown of carbohydrates, fats, and fiber when digestive capacity may be reduced on GLP-1 medications.
Clinically studied to support gastric comfort and digestive ease. One of the most researched botanicals for nausea and digestive comfort commonly experienced during GLP-1 treatment.
View Research →Micronutrients. What reduced food intake may systematically affect.
Research published in Obesity Reviews in 2026 confirmed that caloric intake drops 16 to 39% during GLP-1 treatment. Every vitamin and mineral obtained through food may drop with it. B12 is among the most commonly depleted nutrients in long-term GLP-1 users. Zinc, magnesium, folate, and vitamin D gaps commonly follow. TAKE Complete was formulated to support all of them at clinically meaningful doses.
Among the most commonly depleted nutrients in GLP-1 patients. Critical for nerve function, energy production, and red blood cell formation. Dosed at over 11x the daily value because depleted B12 stores may require meaningful replenishment, not just maintenance.
Supports healthy blood glucose regulation and insulin sensitivity. One of the most evidence-supported micronutrients for people managing metabolic health alongside weight loss on GLP-1 medications.
Supports hair, skin, and nail health that may be affected during rapid weight loss. Works systemically alongside the topical peptides in TAKE Regrowth.
* These statements have not been evaluated by the Food and Drug Administration. TAKE products are not intended to diagnose, treat, cure, or prevent any disease. The science referenced here describes the mechanisms of individual ingredients as supported by published research. Always consult your healthcare provider before starting any new supplement.